Resveratrol And Sabinsa’s Bioperine® On Mitochondrial Capacity With Exercise

June 21, 2016


Sabinsa Corporation manufactures and markets phytonutrients, Ayurvedic herbal extracts and specialty fine chemicals for nutritional, pharmaceutical and food industries. Sabinsa has carved a niche for itself by its extensive research support for its customers and products, and the scientific credentials of its key technical staff. Founded in 1988 by Muhammed Majeed, Ph.D., Sabinsa is a company dedicated to the principles of tradition, innovation and research. Sabinsa's efforts have begun to earn the company vast recognition, in addition to growing sales.

East Windsor, N.J. (June 21, 2016) – A recent human clinical study by the University of Georgia Department of Kinesiology in Athens, Georgia found that Resveratrol fortified with Sabinsa’s BioPerine® increases mitochondrial function. The study, Influence of exercise training with resveratrol supplementation on skeletal muscle mitochondrial capacity by Kristine R. Polley, Nathan Jenkins, Patrick O’Connor, and Kevin McCully, was published in Applied Physiology, Nutrition and Metabolism (41: 26–32 (2016) dx.doi.org/10.1139/apnm-2015-0370). Skeletal muscle mitochondrial performance was shown to increase with consumption of Resveratrol (500mg) and BioPerine (10mg) in this double blind study.

Mitochondria act as the power producers of cells in the body, and are also involved in other cell processes such as cell division and growth. The enzyme triumvirate, PGC1α-SIRT1-AMPK plays a crucial role in mitochondrial biogenesis and Resveratrol aids greatly in the process by enhancing the expression of these three enzymes. BioPerine, by enhancing the bioavailability of Resveratrol, plays an amplifying role.

The study was conducted on participants who ingested the combo Resveratrol + BioPerine for four weeks with moderate exercise. Near infrared spectroscopy was used to study the mitochondrial capacity of wrist flexor muscle of one arm while the other arm served as the control.  

“The study is especially significant for the general population who may be unable to perform high intensity exercise,” said Nagabhushanam Kalyanam, PhD, President of R&D, Sabinsa. “Functionally beneficial mitochondrial-performance is realized even with low intensity exercise with Resveratrol plus BioPerine supplementation.”

This is not the first study to show such activity. Earlier cellular and animal studies published about four years ago by University of Wisconsin demonstrated higher bioavailability of Resveratrol with concomitant administration of BioPerine. The University of Georgia human study further adds credence to the significant role played by BioPerine in augmenting the role of Resveratrol.

About BioPerine®:

BioPerine® is a patented extract obtained from black pepper fruits (Piper nigrum) standardized minimum to 95% Piperine. BioPerine® has been used as a bioavailability enhancer for over 15 years. BioPerine® may be co-administered with various nutrients to enhance their bioavailability in both humans and animals. BioPerine® is the only product sourced out of piperine to obtain a patented status for its ability to increase the bioavailability of nutritional compounds. Secondly, it is the only source from piperine to have undergone clinical studies to substantiate its safety and efficacy for nutritional use. For more information, visit www.bioperine.com.

About Sabinsa Corporation:

Sabinsa Logo Since 1988

Sabinsa's mission is to provide alternative and complementary natural products for human nutrition and well-being. Over the past 27 years, Sabinsa has brought to market more than 100 standardized botanical extracts, and privately funded clinical studies in conjunction with prestigious institutions in support of these products. With more than 100 full-time scientists conducting ongoing research in India and the United States, Sabinsa and parent company Sami Labs Ltd. continue to develop, patent and manufacture phytonutrients for the world market, with ingredients that are both Halal and Kosher. For more information, visit www.sabinsa.com.