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Current
Issues - Newsletter
January 2008
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Phytonutrients to Phytopharmaceuticals:
An Eventful Journey
Message from Dr.Muhammed Majeed, Founder & Chairman |
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Sabinsa Corporation turning twenty
in 2008, remains committed to its
founding principles of "Innovating for
the Future from the Past". Over the
years we adapted phytonutrients with
a history of food and medicinal use to
applications in dietary supplements,
functional foods and cosmetics, for
preventive health maintenance.
With our expertise in phytochemistry,
medicinal chemistry and organic synthesis,
we embarked on developing
innovative molecules and compositions
from nature, for use as therapeutics
in the treatment of chronic disease
conditions
Amilestone in Sabinsa Corporation's
pioneering efforts in the field of phytonutrients
for health and well being,
was achieved in 2006, with the approval
of Ocufors‚ a branded and patented
composition of forskolin eye drops as
a natural drug for the management of
glaucoma, by the Drugs Control General
of India.
Forskolin is the active ingredient in
ForsLean®, Sabinsa's award winning,
and patented, standardized natural
extract, used in dietary supplements
for weight management support.
ForsLean® efficiently
and safely enhances lean
body mass at the expense
of body fat, improving
body composition, and
body mass index (BMI).
The major stumbling
block in the commercialization
of forskolin as an ophthalmic
drug has been its poor water
solubility. For example, the forskolin
eye drops used in clinical trials by
Hoescht Pharmaceuticals was a suspension
of varying concentration of
forskolin which induced side effects
like reddening, itching, lacrimation
and an initial increase in intraocular
pressure (IOP). Currently available
therapeutics for the management
of glaucoma (a leading cause of blindness
globally), offer benefits, but are
associated with side effects and tolerance
development. Research efforts by
Sabinsa Corporation enabled preparing
aqueous solutions of diterpenes such
as Forskolin and its derivatives, using
suitably substituted cyclodextrins as
solubilizing agents improving the
water solubility of forskolin 6,000
fold (US Patent #6,960,300).
| The composition effectively
addresses formulation challenges
that have limited the use of forskolin
as a therapeutic, functional food,
or cosmetic active agent in the past.
Aqueous preparations of forskolin and
related diterpenes are preferable in dermatological,
gynecological, otological,
rhinological and in mucous membrane
applications, and especially useful in
ophthalmic preparations
for the management of
ocular hypertension and
glaucoma. The soluble
forskolin composition is
potentially a first-line natural
therapy in reducing
IOP, based on its safety
in terms of side effect
profile, and its efficacy
in lowering IOP. Drug registration efforts are
underway globally. |
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In 1994, Sabinsa
Corporation introduced
and patented BioPerine®
(black pepper fruit extract)
for use as a bioavailability
enhancer for nutrients.
Tetrahydropiperine, derived
from this extract, improves
the uptake and utilization
of topically applied active
molecules, and received the
Thomas Alva Edison patent
award in 2005. This invention
is relevant to cosmetics,
as well as dermatological
compositions, and topical
drug delivery, wherein it
reduces dose requirements
of potentially toxic actives,
in the treatment of chronic
disease conditions.
Sabinsa Corporation
is now developing natural
molecules and compositions
for the treatment of socially
debilitating conditions such
as psoriasis, and precancerous
conditions such as oral
leukoplakia. We hope to
obtain drug approval for
the patents pending psoriasis
treatment composition
in 2008.
As always, we remain
caring and committed to
the spirit of innovation
in healthcare, and will
continue to provide the
quality ingredients that
you have come to expect
from SABINSA, this year
and in the years to come. |
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Sabinsa Hires Jeff Lind As
Chief Executive Officer |
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Sabinsa Corporation
has announced the
appointment of Jeff Lind
as the company's chief
executive officer, overseeing
all operational
aspects including supply
chain and purchasing
management, as well as
financial expenditures.
As a key member of
Sabinsa's leadership
team, Lind will help to
develop strategic direction
and determine optimal
business practices for the company.
| With a successful executive track
record and comprehensive expertise in
the nutraceutical industry, Lind’s more
than 17 years of business experience
includes leadership roles in sales and
marketing, corporate finance, supply
chain and risk management. Most
recently, he served as
the director of marketing
and sales for a leading
nutritional company,
further cementing his vast
experience in the industry’s
retail and manufacturing
sector. Lind holds a
J.D. degree fromWestern
New England College
School of Law and has
previously practiced
taxation and general
corporate law. |
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"We are excited to
have Mr. Lind join our team of professionals,"
said Muhammed Majeed, Ph.D.
and founder of Sabinsa Corporation. "As
CEO, Jeff brings rich experience and
expertise that will be a tremendous asset
as the company begins a phase of substantial
growth to meet the future needs
of the industry." |
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Jim Cudahy joins Sabinsa Corporation as President and COO |
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| Jim Cudahy graduated from Manhattan
College with a B.S. in Chemical
Engineering. Jim has over 26 years of
experience in the CPG industry, including
two Fortune 100 companies (Kraft and
Kellogg), focused on food and dietary supplements
(Nellson Nutraceuticals). With his
strong experiences in manufacturing, supply
chain, quality, engineering, contract manufacturing
and sales, Jim will provide Sabinsa with
a comprehensive business experience base
upon which we will move into the future. |
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Sabinsa Announces Capability as
Full-Service ContractManufacturer
Utah Site Provides Complete Range of Manufacturing Services in
Addition to Raw Material Offerings |
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Sabinsa Corporation's Payson, Utah contract manufacturing
facility is now fully operational. The additional
17,000-square-foot center provides cutting-edge capabilities
for the development of capsules, tablets, bulk custom
pre-mixes, drum-to-hopper blends, stick packs, and
powdered drinks. |
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Sabinsa's contract manufacturing services include:
Blending - 10,000 kg/shift
Roll compaction - 1,400 kg/shift
Fluid-bed granulation - 3,500 kg/shift
High sheer granulation - 1,400 kg/shift
Comill particle size reduction - 5,000 kg/shift
Tablet compression - 1 MM tabs/shift
Tablet coating - 250 kg/shift
Encapsulation - 1.2 MM caps/shift
Stick Packs - 1.2 MM/shift
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"As a proven supplier of quality raw materials for
nearly two decades, we felt it a natural transition to
extend our offerings to include state-of-the-art manufacturing
services," said Muhammed Majeed, Ph.D.,
founder and CEO of Sabinsa Corporation. "Now, our
customers not only have access to our scientificallybacked
raw materials offerings, but also to valueadded
manufacturing capabilities that meet all of their
formulation needs. This provides finished goods
manufacturers with added convenience, substantial cost
savings and a decreased time to market for products."
Additionally, Sabinsa is working to secureAustralian
TGAand other international regulatory certifications for
this facility to better serve its domestic clients with international
distribution, as well as international clients
presently serviced through other Sabinsa offices globally.
Sabinsa's global network of scientists, expertise in
the development of custom extracts and ingredients, and
ability to provide resources from product inception to
completion results in unparalleled service to its qualityoriented
customers.
For more information visit www.sabinsa.com/
manufacturing. |
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Sabinsa Corporation Awarded Gras
Status for Selenium SeLECT®
Bioavailable and Safe Selenium Ingredient
Confirmed Safe for Use in Foods and Beverages |
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Sabinsa Corporation announced Selenium SeLECT®, the
company's branded L-(+)-Selenomethionine compound
and the most bioavailable, pure and safe form of selenium,
received GRAS (Generally RecognizedAs Safe) designation
after an intensive review of safety and toxicology data
by an independent panel of respected scientists assembled
by Soni &Associates, Inc. This GRAS status allows for
Selenium SeLECT® to be used in a variety of food and
beverage applications including yogurt, flavored milk,
pudding, bread, cookies, pasta, cereal, oils, candies, water,
beverages, tea, herbs and other natural blends.
"As consumers continue to embrace functional foods
and beverages as a major component of a healthy lifestyle,
manufacturers are searching for safe and efficacious ingredients
to improve the nutritional profile of their finished
products," stated Muhammed Majeed, Ph.D., Managing
Director and CEO, Sabinsa Corporation. "Given the
increasing number of ineffective and sometimes dangerous
products on the market today, the proven safety and efficacy
of Selenium SeLECT®, as exemplified by its clinical
research and GRAS status, makes it ideal for inclusion in
a full-array of food and beverage offerings."
Selenium is a trace mineral that is found naturally in soil
and has been shown to have several positive health benefits.
When consumed, selenium enters the body to form
selenoproteins and glutathione, the body's antioxidant
immune system detoxifier. Selenium SeLECT®'s superior
quality as a selenium ingredient is additionally supported
by the following:
The worldwide quality standard or United States
Pharmacopeia (USP) monograph for selenomethionine is
based on Selenium SeLECT®
Selenium SeLECT® is registered and approved by the
European Union as a safe form of selenium supplementation
The National Cancer Institute (NCI) is using Selenium SeLECT® for its Selenium and Vitamin E Cancer Prevention
Trial (SELECT), a 12-year study focused on the role of
selenium and vitamin E, both separately and together, in
the prevention of prostate cancer. Additionally, NCI is
conducting the Prevention of Alzheimer's by Selenium SeLECT® and Vitamin E (PREADVISE) trial, researching
the role of selenium and vitamin E in preventing memory
damage with age, including Alzheimer's and other diseases
that can affect the brain. Selenium SeLECT® was chosen
for these NCI studies because of its high quality.
Selenium SeLECT® has been certified by NSF
International
Selenium SeLECT® is manufactured at Sabinsa's stateof-
the-art facility in India
For more information visit www.seleniumselect.com. |
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Sabinsa's Manufacturing Facilities Receive Funding,
Recognition From Government of India
Grant Aids Sami Labs to Complete Two Novel Research Projects |
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Sabinsa Corporation announced that Sami Labs, its
research and manufacturing arm in Bangalore, India,
received funding from the Government of India's
Department of Scientific and Industrial Research (DSIR)
to perform pilot trials on two novel research projects.
Sami Labs was awarded $185,000 under the
Department's Technology Development and Demonstration
Programme, designed to help promote India's research,
development and technology advancements. The grant will
be used in part to develop and test a plant-derived cosmetic
active, with expected market availability in late 2008. In
addition, the grant will assist Sami Labs in developing a
novel method to manufacture Resveratrol utilizing Sami
Labs' patented synthetic Demethylation strategy.
Additionally, India's National Accreditation Board
for Testing & Calibration Laboratories successfully
audited Sami Labs research & development and quality
control labs. The accreditation certificate provides further
validation of Sami Labs' equipment, analytical
methods, data systems and regulation compliance. |
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SABINSA SECURES PATENT FOR
ForsLean® IN CANADA |
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Sabinsa has secured a patent in Canada for its branded
ingredient ForsLean®, a standardized extract of
Coleus forskohlii roots, the only known plant source of
forskolin, a natural compound that has been shown to
increase lean body mass and help optimize body composition
through cAMP activation. Patent #2281562 protects
the use and preparation of Coleus forskohlii extract
and affirms that ForsLean® is the only such extract that
can legally be used in nutritional supplements for the
purpose of increasing lean body mass in Canada. |
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SABINSA SECURES U.S. PATENT FOR
COCOCIN™ INGREDIENT |
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Sabinsa has secured a U.S. patent for its branded
ingredient Cococin™, a freeze-dried powder form of
green coconut water. In addition to Sabinsa's derivation
process, U.S. patent #7,300,682 secures exclusive
rights to the resulting vitamin-rich composition and
its intended uses in cosmetics, supplements and foods
and beverages to support healthy cell growth and
improve overall dermal health, among others.
Sabinsa's process extracts green coconut water, a
liquid endosperm of maturing coconut, at optimal maturity
when high levels of RNA, critical for amino acid
transport and respiratory metabolism of living cells, are
present. Long considered a refreshing beverage and even
a natural sports drink in SoutheastAsia, CentralAmerica
and other tropical regions, green coconut water has been
valued for its regenerative benefits.
In addition to Cococin™'s U.S. protection, the
branded ingredient was also granted European Patent
#EP1341547 for process, composition and use in the
European Market. |
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SABINSA JAPAN SECURES TWO NEW
PATENTS: BioPerine® &
COSMOPERINE® |
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Sabinsa Corporation has secured patents in
Japan for its branded ingredients BioPerine® and
Cosmoperine®, standardized piperine compositions
derived from black pepper extract.
Patent # JP 3953513 protects the use of piperine
in increasing the bioavailability of the nutrients and
pharmaceuticals. It affirms that BioPerine® is the only
black pepper extract that can legally be used in nutritional
supplements for the purpose of enhancing the
bioavailability of nutrients in Japan.
Patent # JP 4098985 protects the use of tetrahydropiperine
obtained from black pepper using
proprietary process. When included in formulations
with other biological actives, it enhances their
bioavailability and utilization. |
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OTHER NEWS: Evonik Extends Partnership with Sabinsa |
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Evonik Industries and Sabinsa have elevated
their exclusive marketing partnership with the
Personal Care product line of Evonik on a new
level. Evonik will now offer two more specialized,
standardized botanical actives and extracts from
Sabinsa, all specifically developed for cosmeceutical
use, to the personal care industry worldwide.
Evonik will introduce a standardized extract derived
from the seeds of the Horse Chestnut tree for the
cosmetic market. Horse chestnut extract is clinically
proven to benefit people suffering for example from
varicose or spider veins. The second “new entry” is
Xymenynic Acid, obtained from Santalum album
seeds. The standardized powder extract adds an
anti-inflammatory effect to personal care products.
These products are produced at Sami Labs Ltd.,
Sabinsa's national award-winning research &
manufacturing facilities in Bangalore, India and
have been tested for safety and efficacy in their
biological research laboratory by advanced in
vitro systems i.e., cell lines and bioassays. |
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Study Confirms Sabinsa's LeanGard®
Effectively BoostsWeight Loss and
Cuts Body Fat |
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Results of a randomized, double-blind, placebocontrolled
study of 46 overweight men and women
revealed that participants receiving LeanGard® - a
proprietary blend of three of Sabinsa's patented, clinically
researched ingredients, ForsLean®, Garcitrin®
and BioPerine® - had greater overall weight loss and
reduction in body fat, as well as significant increases
in lean body mass, than the placebo group.
The 12-week study, which was conducted at the
Shifaa Hospital in Banglore, India, evaluated the efficacy
and safety of LeanGard® as a dietary intervention
for weight management support against a neutral
placebo. Study participants were given either 500 mg
of LeanGard® or a placebo twice daily and screening
visits were conducted on day zero, as well as at weeks
three, six, nine and 12, to measure Total Body Water
(TBW), Basal Metabolic Rate (BMR), Body Mass
Index (BMI), Waist to Hip Ratio (WHR), Body Fat
Percentage (BF%) and Lean Body Mass (LBM).
Nineteen of the 21 LeanGard® receiving participants
achieved more than a 5 percent reduction in body
weight at the end of 12 weeks. Additionally, the
LeanGard® group showed a mean reduction in BMI of
7.45 percent from the baseline compared to 1.09 percent
for the placebo group, as well as a decrease in body
fat of 8.15 percent compared to 1.18 percent for the
placebo group. A 4.36 percent increase in lean body
mass was also seen in the LeanGard® group versus a 0.67
percent increase from baseline in the placebo group. No
clinically significant changes were observed in blood
pressure or heart rate, hematological liver function,
renal function, thyroid function, plasma lipid levels
or other biochemical parameters.
"With nearly two-thirds of the world's population
overweight, the need for effective products with extensive
scientific validation is more important than ever,"
noted Dr. Lakshmi Prakash, vice president of innovation
and business development, Sabinsa Corporation. "These
study results indicate that LeanGard® helps improve
body composition and mitigate weight gain in overweight
men and women with no apparent side effects."
LeanGard® consists of a proprietary ratio of
ForsLean®, Garcitrin® and BioPerine®. ForsLean® is an
extract derived from Coleus forskohlii roots, and the
only known plant source of forskolin, a natural compound
that has been shown to increase lean body mass
and help optimize body composition through cAMP
activation. Garcitrin® is a composition of calcium salt
hydroxycitric acid (HCA) with garcinol, a polyisoprenylated
benzophenone isolated from Garcinia
cambogia and Garcinia indica fruits, which reduces
fatty acid and lipid synthesis and improves lean body
mass. BioPerine® is a standardized piperine composition
derived from black pepper extract that has been shown
to increase the absorption of nutrients in nutritional
supplement formulations. All ingredients listed above
are patented by Sabinsa for their use. |
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OTHER NEWS: SabinsaWelcomes Benoit Le Gall as
Quality Assurance and Quality Control Manager |
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| Sabinsa Corporation announces the
appointment of Benoit Le Gall, Ph.D. as
quality assurance and quality control manager
for its Payson, Utah facility. Le Gall
will be responsible for upholding TGA
certifications, maintaining FDAcGMP
compliance and managing laboratories,
air handling, water purification systems
and other quality system requirements.
Le Gall comes to Sabinsa with over eight
years of experience as a chemist with a
strong background in quality control and
laboratory practices. His management
background includes a master of business
administration from the Paris Graduate
School ofManagement. |
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Cosmetic Corner: |
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New cosmeceutical product
launches from Sabinsa
MONOLAURIN |
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Monolaurin is a wide spectrum anti-viral,
anti-fungal and anti-bacterial ingredient.
Monolaurin is the glycerol ester of lauric acid,
a 12-carbon chain fatty acid found naturally in breast
milk and certain vegetable oils like coconut oil.
Monolaurin lends itself useful in formulations
requiring antimicrobial activity. It has an MIC of
40/ml i.e., at 0.004% as such against p. acnes and
hence useful in anti-acne preparations. It also has a
potential role as component of a natural preservative
blend. Being a non-ionic surfactant, it can also be
used in anti-microbial soaps and shampoos. |
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GLYCYRRHIZINIC ACID
& MONOAMMONIUM
GLYCYRRHIZINIC ACID |
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Glycyrrhizin, glycyrrhizinic acid or glycyrrhizic
acid, is the active principle of licorice root. It is
a powerful sweetener, 30–50 times as potent as
sucrose. Monoammonium Glycyrrhizinic acid (MAG)
is the water soluble delivery form of Glycyrrhizinic
acid. It is used as an anti-inflammatory and antiallergic
remedy for the treatment of bronchial asthma
and other diseases. It finds applications as a flavor
enhancer and flavoring agents in various food
categories. Topically, MAG can be used in the
form of creams or water based gels in the
management of eczema and other skin disorders. |
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OXYRESVENOX™ |
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OxyResvenox™ is the registered trade mark of
Oxyresveratrol from Sabinsa. Oxyresveratrol is an
analog of Resveratrol and is of synthetic origin.
US Patent 7,253,324, granted to Sabinsa specifically
protects the process for the synthesis of biologically
active polyphenolic compounds like Pterostilbene,
Resveratrol and Oxyresveratrol by novel dealkylation.
OxyResvenox finds potential applications as
an anti-tyrosinase, anti-oxidant and anti-inflammatory
ingredient. In view of skin lightening, de-pigmentation
and anti-inflammatory potential it can also be used in
cosmetic formulations as an anti-aging ingredient. |
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Introducing Natural Colors from
Sabinsa for Nutraceutical and
Cosmeceutical Applications |
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1) Red Sandalwood (Pterocarpus santalinus)
Cosmeceutical Applications
:: To impart glow and shine to the skin in cosmetic
creams, gels, lipsticks and lotions
:: To help wound healing
Nutraceutical Applications
:: Add color and nutrient value to processed food
beverages, candies etc.,
:: Impart red color to alcoholic beverages |
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2) Sappanwood (Caesalpinia sappan)
Cosmeceutical Applications
:: Sappanwood Extract can be incorporated into
cosmetic creams, gels and lotions
:: Its antibacterial property can be utilized effectively
in aftershave lotions
:: It can give bright color and add aesthetic value
to bath soaps
Nutraceutical Applications
:: Add color and nutritional value to citrus drinks
:: Impart color to alcoholic beverages
:: Add nutrient value and aesthetic appeal to
processed foods |
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Sabinsa Corporation Announces Sales and Marketing Agreement with Tempo Canada |
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Sabinsa Corporation announced today
that it has signed a sales and market-ing
agreement with Tempo Canada that
incorporates Sabinsa’s broad range of
nutritional ingredients and integrated
services, in which Tempo Canada will
distribute specialized, standardized
botanical extracts and cosmeceuticals
from Sabinsa, to the personal care &
health care industries in Canada. This collaboration is an important
step for the further development and
the overall commercialization of
Sabinsa's products in the Canadian
market. The goal of this partnership is
to develop and deliver even more
unique products that are safe and effi-cient
which meet the needs of cus-tomers
and consumers by leveraging
the key strengths of each company.
The marketing of the specialized
extracts and ingredients is expected to
launch January 1, 008. This agreement
reflects the changing dynamics in the
healthcare marketplace and Sabinsa is
on the forefront of this positive change.
This partnership is seen as the initial
and first step of a closer collaborative
venture between Tempo and Sabinsa.
Today's announcement underscores
the many solutions that Sabinsaoffersthe
nutraceuticaland cosmeceutical industry,
said Dr. Muhammad Majeed, Founder
Sabinsa Corporation. "We are pleased
that with Tempo we have gaineda strong
partner with excellent marketing expert-ise
and a powerful distribution network
in the field of nutraceutical, cosmeceuti-cal
and specialty ingredients in Canada,who will help us to realize the significant
market potential. This agreement is an
example of Sabinsa's commitment to
bringing innovative nutraceuticals, cos-meceuticals
and specialty ingredients to
market and to establish strategic alliances
with companies that share this commit-ment
with the R&D activities.
Tempo is a well established distributor
of specialty and commodity chemicals,
cosmeceutical ingredients and
nutraceuticals supporting Canadian
manufacturing industries. A dedicated
team of highly skilled professionals is
committed to excellence, responsible
ingredient handling, distribution and
customer satisfaction. "Our strength
lies in building long-term partnerships
with both our clients and our suppliers,
which benefits all parties involved. We
believe in partnerships built on unparalleled
service and the sharing of technical
knowledge and expertise. Helping
manufacturers fit the puzzle together to
produce products that their customers
need, is what Tempo does best," stated
Eno Agro, president, Tempo Canada.
Sabinsa's mission has always been to
provide alternative and complementary
natural products for human nutrition and
overall wellbeing. Over the past years,
Sabinsa has brought to market several
standardized botanical extracts and privately
funded several clinical studies in conjunction
with prestigious institutions worldwide
in support of these products. Withmore than
100 scientists working full time conducting
ongoing researches both in India and the
United States, Sabinsa continues to develop
and patent phytonutrients for the world markets.
Currently, the company holds 35 U.S.
and international patents surrounding several
of its ingredients. Sabinsa has marketing,
sales and distribution offices in the U.S.,
Europe, South Africa, China, Dubai,
Malaysia, Japan and Australia. The corporate
R&D and manufacturing facilities are
located in India. For more information visit
www.sabinsa.com. |
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WHITE PAPERS FREE TO DOWNLOAD |
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Some of the product articles are available
on ourwebsite for free download
by our customers and clients who would
be interested to know more about the
products.
Please log on towww.sabinsa.comand
click on the white papers to freely download
the articles of your choice.
1.Targeting Trace Mineral Bioavailability:
The Case of Selenium
2. Aging, Biomorphosis, Life Span
and Phytonutrients
3. Green CoconutWater
4. Phytonutrients & Nutritional
Interventions for Natural
Immune Support
5. Policosanol - Naturally Healthful
From the Inside & Out
6. Targeting Optimal Nutrient
Absorption with Phytonutrients
7. Probiotics for Health andWell Being
8. Phytonutrients & Nutritional
Interventions to SupportAHealthy
BodyWeight & Composition |
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New Product Development at Sabinsa |
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Sabinsa has always fostered a healthy trend for innovation and no
where is it more obvious than in its New Products. In fact the
company's tag line ‘our innovation is your answer', celebrates the
efforts involved in new product development.
Right from the initial stages of idea generation a keen eye is kept on
consumer benefit. Often times our customers are our best generators of
product ideas. This has helped us to evolve a customer centric approach
to product development. Questions like what is the benefit to the user,
manufacturer and market are commonly asked. Other times we get to
suggest optimizations. One point to keep in mind here is that New
Products alone do not constitute new product development. Every time
an effort is made to improve on an existing ingredient this contributes
to our new product development efforts as well. Optimizing taste,
color, solvent profiles etc. are major advantages depending on the target
market.
When so much is done to create a completely new product or optimize
it, how does one measure the magnitude of the innovation. How
difficult or easy was it to make and market these ingredients? One
way to analyze this would be to compare the innovation with regards
to Newness to the company vs. Newness to market. |
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Changes to augmented product:
Curcumin C3 Complex® Beadlets |
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When the entire contract manufacturing company was having a
tough time working with curcuminoids, Sabinsa listened to them.
The biggest concern of the customers and clients was dust and staining while running the product on their encapsulating
and tableting machines. Curcuminoids as an ingredient
was not a new product to us and they have been in
the market for a very long time. Sabinsa went ahead and
made beadlets that had the curcuminoids embedded in
it. Sabinsa innovated the free flowing Curcumin C3
Complex® beadlets that are dust free and easy to use on
machines.
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Core product revision: BioPerine® |
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The Japanese have a very strong dietary ingredients regulatory
system. They also do not accept some of the conventional
solvents used to extract botanicals in most developed
nations. When the time came for Sabinsa to introduce this
flagship brand into the Japanese market, a hurdle was
raised. The hurdle came in the form of the extraction solvent.
Ethanol was however acceptable. Sabinsa started to
experiment with a strong in-house R&D and after several
interactions optimized a process that would give the 95%
assay of the product with Ethanol for the Japanese market.
Thus was born BioPerine® JP grade. Today the ingredient is
sold worldwide and is Ethanol extracted material. It is safer
and more acceptable—globally.
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Line extensions: Alkanediols |
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Sabinsa has always been strong in the alkanediols
chemistry. This is part of Sabinsa's specialty fine chemicals
product line. Sabinsa has 1, 2 hexanediol in the product list
for many years. This has been used extensively in the
printer inkjet cartridge industry to provide superior ink
flow properties. Sabinsa has listened to its customer who
approached us from a completely different industry to
develop an alkanediol for use in the cosmetics market to
provide viscosity to their moisturing creams, gels and
lotions. Sabinsa identified 1,2 Octanediol and developed its
usage. Sabinsa sells it as a value added excipient and
recently has discovered new applications for this product.
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Newproduct lines:Resvenox® |
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Just out of sheer interest in stilbenes, Sabinsa has been
able to develop several new molecules. Our first product.in this category was a pure resveratrol. After reviewing
the toxicity and safety dosage this product, Sabinsa has
introduced Resvenox primarily for the anti-aging market.
Resveratrol has been a heavily discussed topic in our
industry, but very few have been able to dissect the
chemistry behind the product and develop new/similar
entities. Sabinsa has developed the interest and has made
the products to be the leader in this category. |
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Repositioning: SelenoForce® |
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Sabinsa has been trying tomarket a product by the brand
name of GarliSelect®. Sabinsa used a proprietary hydroponics
technology to enrich garlic pods with selenium and reextract
an array of garlic compounds and selenium
amino-acids from it. Although Sabinsa tried to promote the
selenium supplementation in the ingredient market, most of
the customers saw it as a garlic product. Seeing that
enriched garlic has a completely different connotation to the
customers. Sabinsa embarked on a journey to reposition
this ingredient as a selenium product. GarliSelect® was
branded as SelenoForce®. Sabinsa has already seen customers
getting interested in this concept and getting
involved with the product. |
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Completely new:
Super Critical Fluid Extractions (SCFE) |
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At a time when there was not even an established market
for SCF extracts, Dr. Majeed, Founder, Sabinsa
Corporation, showed a keen interest in developing this technology.
Sabinsa/ Sami Labs teamed up with the Govt. of
India and Indian Institute of Technology to create for the fist
time in India a 100% indigenously built, owned and operated
SCFE factory. This technology was completely new to
the world nutraceutical markets. Many customers have
appreciated the efforts of Sabinsa as pioneers in this field.
Sabinsa has been successful in producing many products
with this technology and serve its customers.
For more information on the new product development
program or to suggest an innovation please contact
the author of this segment—Sendhil Pani, manager
special projects. |
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A Focus on Curcuminoids |
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The chemopreventive roles of dietary
antioxidant phytonutrients against
various forms of cancer are well
researched. These include curcumin,
resveratrol, ellagic acid, green tea catechins,
quercetin and others. Many of
these compounds are reported to provide
health benefits through their
molecular roles in the hepatic cytochrome
P450 monooxygenase system
of enzymes responsible for a major
portion of drug metabolism in humans.
At the fundamental level, phytonutrients
such as quercetin and curcumin
have been shown to up
regulate antioxidant gene expression
in animal models (Shahed, et al;
2001). Interestingly, curcumin is
reported to inhibit the expression of
inflammatory enzymes, as well. Cyclooxygenase
(COX-2) gene expression is
reported to be characteristic of colon cancer
and several high grade tumors. A non-toxic
concentration of curcumin was found to significantly
inhibit the expression of the COX-2 gene, suggesting its
beneficial role against colon cancer (Goel, et al; 2001).
A number of research institutions including The
National Cancer Institute (NCI) in the United States,
are currently in the advanced stages of evaluating
Curcumin as a potential therapeutic intervention in
several degenerative disease conditions associated
with aging. Several of these studies use Curcumin C3
Complex® a branded (trademark of Sabinsa
Corporation) natural extract prepared from turmeric
roots containing curcumin, demethoxycurcumin and
bisdemethoxycurcumin, collectively known as curcuminoids.
Patented for its unique
composition ratio and use, research
shows that C3 Complex is a
‘bioprotectant” that effectively
inhibits free radical
formation and propagation
(Majeed, et al.; US Patent
5,861,415).
The research institutions
involved include UCLA School
of Medicine, University Hospitals of Cleveland, MD Anderson Cancer Center,
Rutgers University, Tufts University
School of Medicine, Massachusetts
General Hospital, Brown University,
Penn State University, and others in
the United States and worldwide.
The multifunctional health benefits
of the curcuminoids are well
researched and these antioxidant
compounds are potentially useful in
preventing inflammation and several
types of cancer (Shishodia, et
al.; 2005). A common spice used in
South Asian cooking, turmeric and
more appropriately the curcuminoids
have been preclinically and/or clinically
validated for beneficial effects in
a number of disease conditions ranging
from Alzheimer's disease to cystic
fibrosis.
The antioxidant effects of curcuminoids
combined with their known inhibitory
effects on cyclooxygenase 2 (Cox-2) render them
useful as ingredients in anti-aging formulations, and in
topical formulations designed to maintain general skin
health and integrity. Oxidative stress and inflammation
are major players in the aging process. The anti-inflammatory
role of curcuminoids is well established.
Curcuminoids have been shown to inhibit nuclear factor
kappaB (NFkB) a transcription factor that triggers
inflammatory mediators. NFkB has been implicated in a
variety of chronic disease conditions ranging from cardiovascular
diseases to cancer (Kumar, et al.; 2004).
Arecent study postulates that curcumin can potentially
slow down aging process (Salvioli, et al.;2007) and is
therefore potentially delays senescence and the onset or
progression of many age-related diseases.
References:
1.Goel,A.et al.Cancer Lett; 2001, 172(2):111-8
2.Kumar A,et al. Journal ofMolecularMedicine 2004;82:434-48.
3.Salvioli S,et al.Evid Based ComplementAlternatMed.
2007; Jun;4(2):181-190.
4.Shahed AR et al.Transplant Proc.2007;33(6):2988
5.Shishodia,S et al, Journal ofMolecularMedicine 2004;82:434-48. |
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"The information presented in the"Current Issues"Newsletter from Sabinsa Corporation is for information purposes only. It is abstracted fromweb and printmedia sources.Readers are advised to refer to the original sources for additional information". |
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Sabinsa's Scientist
Addresses
Complementary
Healthcare Council
in Australia |
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Sabinsa Corporation ofAustralia
was represented by Vladimir
Badmaev, M.D., Ph.D., Vice
President, Scientific and Medical
Affairs, at the CHC's (Complementary
Healthcare Council)
Sponsors' Obligations Conference held recently in
Sydney, October 31st - November 1st. The diverse
range of speakers and content at the Conference
focused on the theme of Evidence in use and practice
of complementary medicine in Australia and other
countries worldwide. The CHC organized the event to
provided information and education on matters affecting
the dynamically growing industry of complementary
medicine in Australia. Dr. Vladimir Badmaev
presented paper titled "Evidence Gathering Methods:
Curcuminoids from Curcuma longa in the fight against
cancer and age related disorders". The presentation
summarized several years experience of Sabinsa
Corporation in preclinical and clinical studies of the
phenolic compounds curcuminoids from Curcuma
longa in cooperation with MD Anderson Cancer
Center, Houston TX, and the UCLA School of
Medicine and Dentistry, LosAngeles CA. Some of the
presented data were recently published: Zhang L, Fiala
M, Cashman J, Sayre J, Espinosa A, Mahanian M,
Zaghi J, Badmaev V, Graves MC, Bernard G,
Rosenthal M. J Alzheimers Dis. 2006 Sep; 10(1):1-7.
The conference was highlighted by Dr. Kerryn
Phelps of the University of Sydney's School of Public
Health and former President of the AMA (Australian
Medical Association) who gave a thought-provoking
opening speech. 'Evidence', she declared, is the
"peacemaker" between allopathic or the western conventional
health paradigm and the complementary
health paradigm. She called for appropriate education
of GP's in undergraduate, postgraduate and continuing
education and concluded by speaking about equity
issues in the provision of complementary health treatments
arguing that unless the due recognition is given
to complementary health treatments, affordability and
access will separate patients into those who can afford
to pay for them and those who cannot.
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NEW U.S.PATENTGRANTED:
SABINSA ISSUED PATENT FOR
PROCESS OF MANUFACTURING
RESVERATROL AND RELATED
POLYPHENOLS |
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Sabinsa Corporation is proud to announce that on August 7,
2007, it has secured U.S. Patent No. 7,253,324 protecting the
process for the synthesis of biologically active polyphenolic compounds
by novel dealkylation. This process of aromatic poly
o-demethylation is applicable in the manufacturing of polyphenols
such as resveratrol, oxyresveratrol and gnetol.
"The review, acceptance and issuing of this patent by the
U.S. Patent and Trademark Office was completed in only six
months, which is a testament to the hard work of our scientific
team and the thoroughness of the information that was submitted
with the patent application on the process, scientific
support and previous references on the subject," stated
Muhammed Majeed, Ph.D., founder and CEO, Sabinsa
Corporation. "This represents our 34th patent worldwide and
underscores our continued innovation surrounding manufacturing
processes for herbal extracts, phytonutrients and specialty
fine chemicals."
This patent covers a wide range of applications in the
multi-step synthesis of pharmaceuticals and fine chemicals.
This streamlined manufacturing process enables easy access
to several known polyphenols and simplifies the course of
action for discovering unknown polyphenolic compounds.
Sabinsa has applied this patented process to manufacture stilbene-
polyphenols exhibiting various health benefits such as
resveratrol, oxyresveratrol and pterostilbene. |
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Sabinsa Corporation Unveils
Manufacturing Facility In India |
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Facility allows Sabinsa to better serve global nutritionmarketwhile growing local economy |
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Sabinsa Corporation has increased its manufacturing
services, in-house laboratory capabilities and production
capacity in 2007 by completing construction
of a $6 million manufacturing facility in Hyderabad,
India. The state-of-the-art building and its 100 estimated
employees will manufacture herbal extracts and
phytochemicals for world markets including the U.S.,
Europe and Japan.
Located in India's Genome Valley, the new plant
covers an area of 200,000-square-feet with a dedicated
60,000-square-foot area which houses a series of testing
labs and manufacturing equipment to ensure optimum
quality control, in addition to providing
headquarters for Sabinsa's research and development
operations. Sabinsa currently operates five additional
manufacturing facilities throughout India. This plant,
like the others uses effluent water treatment systems
and is environmentally conscious and friendly.
"Increased demand for our scientifically backed
ingredients coupled with tremendous business opportunity
in the Genome Valley presented an ideal opportunity
to grow our business and establish a new
manufacturing plant in India," said Dr. Muhammed
Majeed, founder of Sabinsa Corporation. "We are
pleased to have the tools to better serve our customers
while providing a range of employment opportunities that will allow both Sabinsa and the local economy to
flourish."
The new plant focuses on the Sabinsa's aggressive
efforts to develop and research new, innovative and
efficacious products to meet the needs of customers
and consumers. Sabinsa also submits to regular audits
from NSF International to ensure adherence to their
Good Manufacturing Practices standards. Manufacturing
processes, sanitation standards, pest control
methods, personnel training, product testing practices
and standard operating procedures are verified to
ensure they meet with their stringent GMP criteria.
Sabinsa currently operates five additional manufacturing
facilities throughout India and has marketing
offices in the USA,Australia, Europe, Japan, Malaysia
and South Africa. |
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Launch of Herbal Reference
Standards fromSabinsa |
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Herbal reference standards from Sabinsa Corporation set
to improve standards in the growing herbal industry. |
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Sabinsa Corporation has launched the first suite of herbal
reference standards in a planned series of reference materials
for world markets including the U.S., Europe and Japan. |
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There is a rapidly growing awareness both at consumer
and regulatory levels of the need for phytochemical reference
standards and other assurance control methods
throughout the supply chain to ensure the validity, safety
and quality of end products. The growth, sophistication,
and maturation of the herbal market around the world have
inevitably lead to the issue of how herb quality can be
obtained and maintained. |
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Extracted from natural plant materials, Sabinsa's range
of standards are used to identify, verify and quantify the
accurate concentration of the key active compounds or the
markers. The standards can also be used to check for identification,
assay, purity test and toxic or adulterating plant
material.
Extracted from natural plant materials, Sabinsa's range
of standards are used to identify, verify and quantify the
accurate concentration of the key active compounds or the
markers. The standards can also be used to check for identification,
assay, purity test and toxic or adulterating plant
material.
"
We provide the standards with scientific rigor and
offer effective solutions that achieve the integrated view of
the customer in the total supply chain, said Dr.
Muhammed Majeed, founder of Sabinsa Corporation. Our
launch of the Sabinsa's range of botanical and nutraceutical
reference standards is timely for producers of dietary
supplements, functional foods and other plant-derived
healthcare products to achieve the validated results for the
products.
Sabinsa also recommends
which phytochemical
reference
standard to be used for
a specific botanical or
nutraceutical product
and can provide the customers
with cost-effective
supply of botanical
extracts and their reference
standards. |
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RESIDUAL PESTICIDE ANALYSIS: REGULATORY UPDATE |
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The method described in the "Pesticide Analytical
Manual" published by US FDA(Multiresiduemethods
Volume I 3rd Edition 1994, Updated October,
1999) is currently used to quantitate residual pesticides
and herbicides in natural extracts. This method is time
consuming, and necessitates using a specific pesticide
"reference standard" for each and every such component.
The number of pesticide/herbicide compounds
that can be identified by this method is therefore limited
by the complexity of the method.
On November 29, 2005, the Japanese government
published a "positive list system for the regulation of
pesticides, feed additives and veterinary drugs.
Maximum Residue Limits (MRL) are set for 758
chemicals, while 65 other compounds are exempted
from regulation. Fifteen substances must have no
detectable residues. Other agricultural chemicals not
mentioned specifically, have a uniform MRL of
0.01ppm. The regulation is in effect from May 29,
2006.With the appearance of this list international customers
(Japan, Europe and USA) now wish to test
products for the 758 chemicals identified therein. |
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Sabinsa Ensures Compliance |
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Sabinsa Corporation has identified the GC-MS
method and GC-MS Library from Agilent Technologies,
to enable efficient testing. This method and
software enable the rapid identification of 926 pesticides
and endocrine disrupters (the test per sample is
completed in about two minutes, the conventional
method takes two days to complete). In addition carcinogenic
compounds such as polycyclic aromatic
hydrocarbons (PAH), polychlorinated biphenyls (PCB)
and Sudan dyes can also be quantified. The database
contains all the analytes specified for GC/MS analysis
in the new Japanese “positive list” regulations.
This is the fastest, most comprehensive, most accurate
method for screening food samples. |
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References:
1. www.agilent.com
2. Introduction to positive list system for agricultural
chemical residues in foods department of safety,Ministry
of health, labor and welfare. http://www.mhlw.go.jp/
english/topics/mrls/mrls.html |
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SABINSA MANUFACTURING |
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Advantages: |
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- International Regulatory Expertise
- Primary Manufacturer From Field To Market
- Custom Extraction & Ingredient Development
- Proven Quality Supplier For Nearly Two Decades
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Services: |
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- Stick Pack Manufacturing
- Tablets, Capsules, Customized Blends
- Granulation, Roll Compaction, Blending
- Dedicated Curcumin Manufacturing Facility
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Our Additional Product Websites |
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