The patent describes an essential oil composition from Coleus forskohlii used in compositions and methods for the treatment of skin infections and in the prevention and treatment of dental caries.

Coleus oil is an essential oil extracted from the roots of Coleus forskohlii using a proprietary, solvent-free supercritical carbon dioxide extraction process. The oil finds useful applications in flavor and fragrance preparations as well as in aromatherapy. The Sabinsa patent focuses on novel applications in skin care and oral care preparations wherein a composition of the oil was shown to have potent antimicrobial activity.

This oil composition is particularly effective against Propionibacterium acnes, the microorganism implicated in the acne as well as against other microbes known to cause skin infections. Another potential application is in oral care products where the oil was found to be effective in preventing the growth of Streptococcus mutans, a causative microorganism for dental caries.

Over forty compounds belonging to four classes of aroma compounds have been recovered from oils obtained from various indigenous genotypes of the Coleus forskohlii.. These include sesquiterpenes, sesquiterpene alcohols, monoterpenoids and diterpenoids. The process patented is for a novel composition of the oil prepared using solvent free supercritical extraction to concentrate the antimicrobial compounds in optimal proportions.

Sabinsa’s range of mineral nutrients (listed on the back page of this letter) are carefully prepared to ensure optimal bioavailability. Magnesium, calcium, potassium and zinc are supplied in better absorbed organic forms as ascorbates, aspartates, citrates, malates or methionates.

A comprehensive listing and detailed product information are available on www.sabinsa.com/minerals

According to the organizers of the show, a record-setting 5,126 industry executives from dietary supplement, food, pharmaceutical and cosmetic companies attended the trade show event and conference which provides numerous networking opportunities for suppliers and manufacturers.

Products featured at the show included Bioperine®, ForsLean®, Citrin® K, Gugulipid®, Citrin® 65, GarliSelect®, Methylselenocysteine and Sabinsa Cosmeceuticals.

If you missed us at the show, contact your sales executive or simply write to info@sabinsa.com for your complimentary info packet on any of these products.

1. Incompatibility with binder or solvent 
   
   
2. To maintain purity and assay of raw material no excipient can be added
   
   
3. Wet granulation may not be increasing the bulk density to desired level
   
   
4. Incompatibility of raw materials in presence of solvent

Dry granulation also works as precompression and helps to eliminate entrapped air due to porosity of powder. This increases the density of the material. There are two common procedures for dry granulation:

1. Slugging
   
   
2. Roll compaction or chilsonation

In slugging, the material is slugged on a compression press using big tooling. This requires a heavy-duty press. The slugs are then crushed and sized to the customer’s requirements. This process is slow and occupies costly press. However, the process can be used for small trials. Slugging is problematic with products with poor flow characteristics as they do not flow in die cavity very well and hence adequate pressure is not applied on the material.

In roll compaction, specialized Roll Compactor machine or Chilsonator is used. The basic concept of this machine is to force fine powder between two counter rotating rolls. As the product reaches maximum pressure zone the volume of the product reduces and material gets converted in a sheet or solid compact (like a stick of chalk) depending on type of roll used. Above the compaction zone there is a cylindrical conical feed screw in a hopper. The material is feed through this feed screw to the compaction zone. The feed screw helps in the flow of the material so material with poor flow, or practically no flow, can be processed on this machine.

In the dry granulation process, addition of lubricants and dry binders is highly recommended. They reduce the percentage of fines and improve the efficiency of the compaction process. “Fines” are fine, dry particles that do not flow well (causing weight variations), and do not compress well (contributing to defects such as capping and lamination of tablets).

Sabinsa uses Roll Compactor to custom compact various products. Some of the products successfully compacted include Citrin®, Amino acids, Garlic powder, Elderberry extract and Gugulipid®.

Sabinsa conducts a free feasibility study on the customer’s product. Trial quantities range from 5-20 Kgs. Depending on requirements, compacted slugs or sized material can be provided.

Look for Part III in next month’s issue.

Chemical Market Reporter, Soaps & Cosmetics, Functional Foods & Nutraceuticals, Natural Products Insider.