Sabinsa’s line of cosmeceuticals has expanded. (Cosmeceuticals are ingredients with medicinal properties that manifest beneficial topical actions or provide protection against degenerative skin conditions.) Besides our well known products, Aleuritic acid, Boswellin® CG, Cosmoperine®, Green Tea CG, Rosemary Extract CG, Rosmarinic acid, Tetrahydrocurcuminoids, Ursolic acid (50% & 90%), and VenocinTM (Horse Chestnut Extract), Sabinsa supplies the following cosmeceuticals that may be included in formulating finished cosmetic products (e.g. creams, lotions, shampoos, body washes, deodorants, toothpastes, lip balms, etc.)

Alpha-Lipoic Acid
Alpha-Lipoic Acid is an effective antioxidant nutrient that has been reported to protect the body against several degenerative diseases attributed to free radical damage.1 Alpha-lipoic acid’s antioxidant effects are also beneficial topically.2

Structure of Alpha-Lipoic Acid

Arjunolic Acid
Arjunolic Acid is a constituent of the heartwood and bark of Terminalia arjuna. T. arjuna is a large, woody tree indigenous to India.3 Bark extracts of T. arjuna have been reported to suppress the growth rate of human transformed cells4 and modulate the mutagenicity of mutagenic strains of S. typhimurium.5 In a preliminary study, arjunolic acid and its derivatives were reported to inhibit skin tumor promotion in Epstein-Barr virus early antigen (EBV-EA) activation in Raji cells.6

CococinTM
CococinTM, a trademark of Sabinsa Corp., is freeze-dried ,coconut water solids. In view of coconut water solids’ role in supporting cell growth7, CococinTM may be used in applications (e.g. hair care formulations and rejuvenative topical preparations) that support the growth of human tissues.

Centellin®
Centellin® Extract CG, a registered trademark of Sabinsa Corp., is a standardized extract of Centella asiatica, a botanical that has wound healing and anti-aging properties.8-9

Coleus Forskohlii Extract (95% Forskolin)
Coleus Forskohlii Extract (95% Forskolin) is a standardized extract prepared from the roots of the Coleus forskohlii plant. In a clinical study, an ointment containing forskolin was reported to topically reduce the fat in women’s thighs.10

Coleus Forskohlii Oil
Coleus Forskohlii Oil is an oil extracted from the roots of the C. forskohlii plant. The oil contains a range of aroma constituents that collectively impart a characteristic aroma.11 Thus, it may be used in perfumery and aromatherapy products. The oil also has antimicrobial properties that make it useful in skin and dental preparations.12

Licorice Extract CG
Licorice Extract CG is a standardized, powdered extract prepared from the roots of Glycyrrhiza glabra. Licorice extract’s skin whitening and anti-inflammatory properties make it a useful ingredient in topical applications.13

Oleuropein
Oleuropein, a constituent of olive leaves and olive oil, has been reported to furnish antioxidant14-16, anti-inflammatory17-18, and antimicrobial19-20 effects.

SapindinTM
SapindinTM is Sabinsa’s trademark for Soapnut Saponins, a product prepared from the fruit (nuts) of the Soapnut tree, Sapindus trifoliatus. The Soapnut tree is a rich source of saponins that function as a mild cleanser and antimicrobial.21

Turmeric Oil
Turmeric Oil is extracted from the roots of the Curcuma longa (Turmeric) plant. The oil is reported to furnish antimicrobial22-23 and insect-repellant24 effects.

Cosmoperine®
A cosmeceutical that augments the efficacy of administered topical ingredients is Cosmoperine®, Sabinsa’s natural, skin permeation enhancer prepared from piperine, the active principle of black pepper (Piper nigrum) and long pepper (Piper longum). Cosmoperine® can be added to finished cosmetic products (e.g. lotions, creams, balms, etc.) to enhance the absorption of the active compounds and nutrients in the formulations.

Sources:

1. Packer, L. et al. (1995) Free Radic. Biol. Med. 19, 227-250.
2. Podda, M. et al. (1996) Biochem. Pharmacol. 52, 627-633.
3. Kumar, D. et al. (1987) J. Ethnopharmacol. 20, 173-190.
4. Nagpal, A. et al. (2000) In vitro Cell. Dev. Biol. Anim. 36, 544-547.
5. Kaur, S. (2001) J. Environ. Pathol. Toxicol. Oncol. 20, 9-14.
6. Diallo, B. et al. (1989) J. Nat. Prod. 52, 879-881.
7. Tulecke, W. et al. (1961) Contrib. Boyce Thompson Inst. 21, 115-128.
8. Shukla, A. et al. (1999) Phytother. Res. 13, 50-54.
9. Shukla, A. et al. (1999) J. Ethnopharmacol. 65, 1-11.
10. Greenway, F. et al. (1995) Obesity Res. 3, 561S-568S.
11. Misra, L. et al. (1994) J. Essent. Oil Res. 6, 243-247.
12. Sabinsa Research Study (February 2000).
13. Yokota, T. et al. (1998) Pigment Cell Res. 11, 355-361.
14. Speroni, E. et al. (1998) Phytother. Res. 12, S98-S100.
15. Visioli, F. et al. (1998) Biochem. Biophys. Res. Comm. 247, 60-64.
16. Saija, A. et al. (1998) Int. J. Pharm. 166, 123-133.
17. de la Puerta, R. et al. (2000) Z. Naturforsch [C] 55, 814-819.
18. de la Puerta, R. et al. (1999) Biochem. Pharmacol. 57, 445-449.
19. Aziz, N. et al (1998) Microbios 93, 43-54.
20. Koutsoumanis, K. et al. (1998) J. Appl. Microbiol. 84, 981-987.
21. Tanaka, O. et al. Application of Saponins in Foods and Cosmetics: Saponins of Mohave yucca and Sapindus mukurossi. In: Saponins Used in Food and Agriculture. George R. Waller and Kazuo Yamasaki eds. Advances in Experimental Medicine and Biology Volume 405, Plenum Press, 1996, pages 1-11.
22. Apisariyakul, A. et al. (1995) J. Ethnopharmacol. 49, 163 - 169.
23. Negi, P. et al. J. Agric. Food Chem. (1999) 47, 4297-4300.
24. Roth, G. et al. (1998) J. Nat. Prod. 61, 542-545.

Selenium and vanadium are reported to mimic the blood sugar regulatory functions of insulin in laboratory studies. Insulin regulates cellular and metabolic processes as well as gene expression. The insulin-like actions of selenium and vanadium include participation in glycolysis, in the pentose phosphate pathway and in fatty acid synthesis. Selenium is also reported to play a role in reducing the oxidative stress associated with diabetes.1

The mechanism by which selenium mimics insulin action is not clear. Reports indicate that selenium activates key proteins involved in the insulin-signal cascade. Various proteins in the insulin-signal cascade have been shown to be necessary for different insulin-regulated events.2

Berg et al.3 reported that administration of vanadate or selenate to streptozotocin-induced diabetic rats not only normalized blood glucose levels in a manner similar to insulin but also positively affected the expression of two key metabolic enzymes, glucose-6-phosphate dehydrogenase (G6PDH) and fatty acid synthase (FAS). Both G6PDH and FAS activity are reported to significantly decrease in diabetic animals compared to non-diabetic controls. Treatment of the diabetic animals with either insulin, vanadate or selenate restored the activities of both enzymes to about 80-90% of their normal values. (The main biological function of G6PDH is to support reductive biosynthesis as well as to maintain an environment in the tissue, thereby preventing free radical induced damage leading to cataract formation4 and other secondary complications of diabetes.)

Sources:

1. Mukherjee, B. et al. (1998) Biomed. Pharmacother. 52, 89-95.
2. Stapleton, S.R. (2000) Cell. Mol. Life Sci. 57, 1874-1879.
3. Berg, E.A. et al. (1995) Biochimie 77, 919-924.
4. Zhao, W. et al. (1998) Free Radic. Res. 29, 315-320.

Selenium SeLECT®, a registered trademark of Sabinsa Corporation, is supplied as two grades of L-(+)-Selenomethionine (LSM), an organic, bioavailable and molecularly integrated (not a dry blend of selenium and methionine) form of selenium. Selenium SeLECT® Pure contains a minimum of 400,000 mcg of elemental selenium (40%) per gram, and Selenium SeLECT® 5000 (DCP blend), a trituration of LSM and dicalcium phosphate, contains a minimum of 5,000 mcg of elemental selenium (0.5%) per gram. Sabinsa’s LSM conforms to USP monograph standards.

Please contact Sabinsa for information about products from our cosmecutical, nutritional, and functional food lines.

Sabinsa Corporation will participate in the following trade show event in July 2001.
July 9-11, 2001: Nutracon 2001 (San Diego, CA) Booth #39