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Current
Issues - Newsletter
June 1997 |
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The
Natural results of Sabinsa R & D : Biotransformations
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Biotransformations
involve the use of biological systems (whole cells, extracts
or isolated enzymes) to catalyze the conversion of one
chemical compound to another. Microorganisms, in the
course of their normal metabolic activities, are capable
of performing complex chemical reactions in a surprisingly
short time that otherwise would require elaborate reactor
setups. As a result, sizable quantities of natural products
can be obtained with minimal effort using selected microbial
cultures.
The current focus at Sabinsa R&D in this area is
on the biogeneration of natural flavors for use in food,
beverage and pharmaceutical applications. Selected strains
of yeast, when grown in specially formulated media,
under carefully controlled conditions, convert compounds
such as amino acids and fatty acids into flavor compounds
such as alcohols, esters and lactones. By controlling
the process conditions, biogeneration may be favored
over growth of yeast cells. The resultant products are
isolated by extraction processes and concentrated to
yield useful flavor compounds.
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Sabinsa Introduces unique process for the manufacture of Glucosamine
Sulfate |
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Sabinsa
recently announced the introduction of a unique, new
process for the manufacture of Glucosamine Sulfate.
This new process incorporates the use of potassium
rather than sodium as a bonding agent, creating a
safer, higher quality product with increased absorption.
Demographically speaking,
the most common use of Glucosamine Sulfate in conjunction
with symptoms of arthritis is found among senior citizens.
Consistent use of a sodium based product poses an
additional risk for those already concerned about
their daily intake of sodium.
Sabinsa's new patent-pending
process for a potassium based product eliminates the
risk of increased sodium intake and provides a high
quality alternative with increased absorption characteristics. |
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Scientific Focus : Eric Yang Ph.D. Sabinsa Research Group
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Senior
Manager of Research and Development, Dr. Yang
is involved in the research and development
of numerous new products, including natural
flavors, specialty chemicals, nutraceutical
products and pharmaceutical intermediates.
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Dr. Yang has extensive
experience in the synthesis and application
of numerous biochemical, organic and natural
elements. These include peptides, antihistamines,
anticancer intermediates and aroma chemicals,
just to name a few.
Dr. Yang received his M.S. and
Ph.D. in Organic Chemistry from West Virginia
University. His experience includes postdoctoral
work at the University of Minnesota and Rutgers
University, and as Senior Chemist at Elan Chemical
Co. |
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Lesser
Known Ayurvedic Gems |
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Inula
Rasemosa
A powdered extract, standardized to 2% allantolactone,
Inula rasemosa has been attributed with various medicinal
properties, e.g. benefiting circulation. Recent findings
also report activity in the lowering of blood cholesterol.
Momordica
Charantia
Also known as Bitter-melon, Momordica charantia is standardized
to not less than 2% bitter principles. Clinical studies
have revealed its capacity to lower blood glucose. Bitter-melon
is also beneficial in managing the situations needed
to promote the healing and regenerative processes in
general. |
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New
Product : lndole-3-carbinol |
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Sabinsa
has added a new product to its list of standardized
botanicals and fine chemicals, Indole-3-carbinol, a
compound which occurs naturally In cruciferous vegetables.
Indole-3-carbinol will be manufactured at Sabinsa's
pilot plant in Princeton, New Jersey.
Indole-3-carbinol is found in cabbage,
broccoli and brussels sprouts and has been shown in
pre-clinical experiments to be a promising anti-cancer
nutrient. This fact may justify well published clinical
evidence that eating cruciferous vegetables prevents
various forms of cancer in humans.
A considerable body of pre-clinical evidence
has been accumulated on the efficacy of Indole-3-carbinol
in the prevention and intervention of direct and indirect
acting carcinogens in the development of breast tumors
in rodents.
In
addition to its potential with breast carcinoma,
Indole-3-carbinol was successfully used in experiments
involving gastrointestinal and lung cancers. It
also shows potential in cardiovascular health,
since it lowered total cholesterol, LDL and VLDL
in hypercholestrolemic rodents by inhibiting the
cholesterol converting enzyme acyl-CoA: cholesterol
acyltransferase.
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Indole-3-carbinol emerges
as a distinct anti-cancer nutritional compound which
differs in mechanism from other cancer fighting nutrients
such as green and black tea. It therefore is a versatile,
nutrition-derived protector against cancer which can
be used alone or in combination with other similar nutrients. |
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| "The information
presented in the "Current Issues" Newsletter
from Sabinsa Corporation is for informational purposes
only. It is abstracted from web and print media
sources. Readers are advised to refer to the original
sources for additional information". |
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