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Current
Issues - Newsletter
April 1997 |
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Spices
Board of India Honors Dr. Majeed
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The
Indian government has again recognized Dr. Muhammed
Majeed for his continuing efforts in new product
development.
The Spices Board of India honored Dr. Majeed for
pioneering the development and commercialization
of Garcinia cambogia.
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New Products : Bacopin™ (Bacopa monniera) |
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Often
referred to as brahmi, Bacopa monniera was prized
by Ayurvedic physicians as an effective brain tonic.
Bacopin™ contains bacosides, the active principles
responsible for improving memory related functions.
These compounds are attributed with the capability
of enhancing the efficiency of transmission of nerve
impulses, thereby strengthening memory and cognition.
Bacopin™ is a trademark
of Sabinsa Corporation. Please feel free to call for
more information, or to speak directly with one of
our scientific staff consultants about Bacopin or
other quality Sabinsa products. |
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Glucosamine S04 Vs. HCl Which is
the preferred form?
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Glucosamine
sulfate is the preferred form of glucosamine for therapeutic
use, mainly as an antiarthritic agent. It is an effective
means of providing glucosamine orally and as a building
block for the regeneration of cartilage glycosaminoglycans
lost during the progression of osteoarthritis.
- Glucosamine sulfate occurs naturally
in the human body and is almost devoid of toxicity,
making it suitable for long-term clinical use1.
- The chondrometabolic, antireactive and
antiarthritis properties of this form have been investigated
extensively and are supported by controlled clinical
trials2.
- Pharmacokinetic studies revealed that
close to 90% of orally administered glucosamine sulfate
is absorbed3.
- Glucosamine sulfate, in vivo, breaks
down into glucosamine and sulfate ions. Glucosamine
hydrocholoride, on the other hand, breaks down into
glucosamine and free hydrochloric acid. The acid would
increase gastric acidity and produce the associated
disturbances in vivo.
- The sulfate ions produced from glucosamine
sulfate, on the other hand, participate in chondrometabolic
processes. They influence the incorporation of glucosamine
and sulfate into the tissues. In a study with gastric
mucosal segments, a sulfate content of 300µ
mole was found to induce maximum incorporation. Chlorate
was found to inhibit glycosylation and induce the
formation of low molecular weight mucin polymer. The
results of this study revealed that sulfate availability
is essential for the formation of high molecular weight
mucin polymer. The presence of sulfate ion would therefore
enhance the antiarthritic properties of glucosamine.
References:
- Rovalti, L.C., (1992). Antireactive
properties of chondroprotective drugs. Int. J. Tissue
Reactions, 14(5), 253-261.
- Reichelt, A. et al. (1994). Efficacy
and safety of intramuscular glucosamine sulfate in
osteoarthritis of the knee, a randomized, placebo-controlled
double blind study. Arzneim-Forsch Drug Res. 44(l)(1),
75-80.
- Setnikar, 1. et al. (1993). Pharmacokinetics
of glucosamine in man. Arzneim-Forsch Drug Res. 43(11)(10),
1109-1113.
- Liau, Y. H. et al. (1992). Role of sulfation
in post-translational processing of gastric mucins.
Int. J. Riochem. 24(7), 1023-1028.
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Scientific
Focus : Sam P. Kumar Ph.D., Sabinsa Research Group |
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Senior
Director of Natural Products Chemistry, Dr. Kumar
takes primary responsibility for developing new
products from natural sources to address serious
medical conditions.
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Dr. Kumar has 23 years experience
as an organic chemist. His experience includes
the successful synthesis of peptides, hormones,
Prostaglandins, antiinflammatorv drugs, antivirals,
antihistamines and aroma chemicals.
Prior to joining
Sabinsa, he was Senior Staff Chemist at Yale
University, and served as Organic Biochemist
for Elan Chemicals, Newark, NJ. He holds a number
of patents and is widely published in professional
journals.
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Sabinsa
receives kosher certification |
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Sabinsa
recently announced that it has been authorized by the
Orthodox Union to place the O.U. symbol certifying products
listed under their respective brand names as kosher
and pareve.
A copy of Sabinsa's kosher certified
product list is available upon request.
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Sabinsa-on-wheels
update : Colorado and arizone |
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| Sabinsa's
educational training seminar will be presented
at the Denver Marriott South (Englewood,
Colorado) on May 14, and the following day
at the Sheraton Mesa Hotel (Mesa, Arizona)
on May 15.
For reservations contact Sabinsa at 908-777-1111
(8:30 a.m. - 6 p.m. EDT).
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| "The information
presented in the "Current Issues" Newsletter
from Sabinsa Corporation is for informational purposes
only. It is abstracted from web and print media
sources. Readers are advised to refer to the original
sources for additional information". |
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